Recent research has yielded many interesting and potentially important therapeutic targets
in sepsis. Specifically, the effects of antagonistic anti-cytokine therapies (tumor necrosis …

Lymphocyte apoptosis plays a central role in the pathophysiology of sepsis. Lymphocyte
apoptosis was examined in mice with defective death receptor pathways due to transgenic …

Background This study examined the effect of microRNA-125b (miR-125b) on sepsis-
induced cardiac dysfunction. Methods Mouse hearts were transfected with lentivirus …

We examined the effect of modulating phosphoinositide 3-kinase (PI3K) activity in a murine
model of cecal ligation and puncture-induced polymicrobial sepsis. Inhibition of PI3K activity …

Sepsis with subsequent multiple-organ dysfunction is a distinct systemic inflammatory
response to concealed or obvious infection, and it is a leading cause of death in intensive …

The increasing prevalence of inflammatory diseases and the adverse effects associated with
the long-term use of current anti-inflammatory therapies prompt the identification of …

Sepsis‑induced cardiac dysfunction is one of the most common types of organ dysfunction in
sepsis; its pathogenesis is highly complex and not yet fully understood. Cardiomyocytes …

Vascular endothelial cells are major participants in and regulators of immune responses and
inflammation. Vascular endotheliitis is regarded as a host immune-inflammatory response of …

Caspase-11 is an essential mediator of septic shock response and caspase-11-deficient
mice are resistant to LPS-induced shock. Here we report that LPS-induced caspase-11 …

Ethnopharmacological relevance Shenfu injection (SFI) is a well-known Chinese herbal
medicine widely used in the treatment of septic shock in China. Aims The aims of this study …