Проточная цитометрия в биомедицинских исследованиях

АВ Зурочка, СВ Хайдуков, ИВ Кудрявцев… - 2018 - elibrary.ru
В монографии изложены современные взгляды на применение проточной
цитофлуориметрии в норме и при различных патологических процессах. Приведена …

Pathways mediating resolution of inflammation: when enough is too much

JN Fullerton, AJ O'Brien, DW Gilroy - The Journal of pathology, 2013 - Wiley Online Library
Patients with critical illness, and in particular sepsis, are now recognized to undergo
unifying, pathogenic disturbances of immune function. Whilst scientific and therapeutic focus …

Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis

C Oberholzer, A Oberholzer… - Proceedings of the …, 2001 - National Acad Sciences
Sepsis remains a significant clinical conundrum, and recent clinical trials with anticytokine
therapies have produced disappointing results. Animal studies have suggested that …

Staphylococcus aureusα‐toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor‐α and the mitochondrial death …

B Haslinger, K Strangfeld, G Peters… - Cellular …, 2003 - Wiley Online Library
Staphylococcus aureus infections can result in septic and toxic shock with depletion of
immune cells and massive cytokine production. Recently, we showed that, in S. aureus …

Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses

A Matsuda, A Jacob, R Wu, M Aziz… - Journal of Nippon …, 2012 - jstage.jst.go.jp
Sepsis is a devastating and complex syndrome and continues to be a major cause of
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …

Histone deacetylation inhibitors as therapy concept in sepsis

A von Knethen, B Brüne - International journal of molecular sciences, 2019 - mdpi.com
Sepsis is characterized by dysregulated gene expression, provoking a hyper-inflammatory
response occurring in parallel to a hypo-inflammatory reaction. This is often associated with …

Susceptibility to programmed cell death in T-lymphocytes from septic patients: a mechanism for lymphopenia and Th2 predominance

G Roth, B Moser, C Krenn, M Brunner… - Biochemical and …, 2003 - Elsevier
Sepsis causes lymphopenia which is inversely correlated with patient survival. The role of
apoptosis-specific immune-activation and activation-induced cell-death in sepsis is …

Sialic acid rescues repurified lipopolysaccharide-induced acute renal failure via inhibiting TLR4/PKC/gp91-mediated endoplasmic reticulum stress, apoptosis …

CC Yang, CA Yao, JC Yang, CT Chien - Toxicological Sciences, 2014 - academic.oup.com
Lipopolysaccharides (LPS) through Toll-like receptor 2 (TLR2) and Toll-like receptor 4
(TLR4) activation induce systemic inflammation where oxidative damage plays a key role in …

Alpha-lipoic acid attenuates oxidative damage in organs after sepsis

F Petronilho, D Florentino, LG Danielski, LC Vieira… - Inflammation, 2016 - Springer
Sepsis progression is linked with the imbalance between reactive oxygen species and
antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic …

Pathological conditions re-shape physiological Tregs into pathological Tregs

WY Yang, Y Shao, J Lopez-Pastrana, J Mai… - Burns & …, 2015 - academic.oup.com
Abstract CD4+ FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an
essential role in maintaining peripheral immune tolerance, controlling acute and chronic …