Cancer remains a leading cause of morbidity and mortality worldwide. Hence, the increase
in cancer cases observed in the elderly population, as well as in children and adolescents …

ATP-binding cassette (ABC) transporters, acting as cellular “pumps,” facilitate solute
translocation through membranes via ATP hydrolysis. Their overexpression is closely tied to …

The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …

ATP-binding cassette transporter G2 (ABCG2) is an efflux transporter related to the clinical
multidrug resistance (MDR) phenomenon. Identifying ABCG2 inhibitors could help discover …

In recent years, the incidences and mortalities from colorectal cancer (CRC) have been
increasing; therefore, there is an urgent need to discover newer drugs that enhance drug …

The pivotal role of MRP3 protein in acute leukaemia and the efficacy of natural compounds
in cancer treatment have necessitated the current study to identify novel MRP3 inhibitors …

AcrAB-TolC tripartite efflux pump, which belongs to the RND superfamily, is a main multi-
drug efflux system of Escherichia coli (E. coli) because of the broad resistance on various …

The ATP-binding cassette (ABC) and solute carrier (SLC) transporters are critical
determinants of drug disposition, clinical efficacy, and toxicity as they specifically mediate …

The human P‐glycoprotein (P‐gp) and the NorA transporter are the major culprits of
multidrug resistance observed in various bacterial strains and cancer cell lines, by extruding …

The role of interleukin-8 (IL-8) and its receptor CXCR2 in inflammatory responses and tumor
development and progression has been well documented. Our study aims to discover novel …