NF‐κB signaling in inflammation and cancer
T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …
in 1986, extraordinary efforts have been made to understand the function and regulating …
The diverse and complex roles of NF-κB subunits in cancer
ND Perkins - Nature Reviews Cancer, 2012 - nature.com
It is only recently that the full importance of nuclear factor-κB (NF-κB) signalling to cancer
development has been understood. Although much attention has focused on the upstream …
development has been understood. Although much attention has focused on the upstream …
NF-κB in cancer: from innocent bystander to major culprit
M Karin, Y Cao, FR Greten, ZW Li - Nature reviews cancer, 2002 - nature.com
Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …
involved in the inflammatory and innate immune responses. Although the importance of NF …
Aberrant rel/nfkb genes and activity in human cancer
B Rayet, C Gélinas - Oncogene, 1999 - nature.com
Rel/NF-κB transcription factors are key regulators of immune, inflammatory and acute phase
responses and are also implicated in the control of cell proliferation and apoptosis …
responses and are also implicated in the control of cell proliferation and apoptosis …
Mutations in the NF-κB signaling pathway: implications for human disease
G Courtois, TD Gilmore - Oncogene, 2006 - nature.com
The nuclear factor-kappa B (NF-κB) signaling pathway is a multi-component pathway that
regulates the expression of hundreds of genes that are involved in diverse and key cellular …
regulates the expression of hundreds of genes that are involved in diverse and key cellular …
Nuclear transcription factor-κB as a target for cancer drug development
A Garg, BB Aggarwal - Leukemia, 2002 - nature.com
Nuclear factor kappa B (NF-κB) is a family of inducible transcription factors found virtually
ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been …
ubiquitously in all cells. Since its discovery by Sen and Baltimore in 1986, much has been …
KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-κB binding to the promoter as a consequence of IκBα-induced block of p65/p50 …
C Yan, H Wang, DD Boyd - Journal of Biological Chemistry, 2001 - ASBMB
The 92-kDa type IV collagenase (MMP-9) plays a critical role in tissue remodeling. We
undertook a study to determine whether the KiSS-1 gene, previously shown to suppress …
undertook a study to determine whether the KiSS-1 gene, previously shown to suppress …
Targeting NF-κB in hematologic malignancies
T Braun, G Carvalho, C Fabre, J Grosjean… - Cell Death & …, 2006 - nature.com
The transcription factor nuclear factor kappa B (NF-κB) can intervene in oncogenesis by
virtue of its capacity to regulate the expression of a plethora of genes that modulate …
virtue of its capacity to regulate the expression of a plethora of genes that modulate …
NF-κB and human cancer: what have we learned over the past 35 years?
TD Gilmore - Biomedicines, 2021 - mdpi.com
Transcription factor NF-κB has been extensively studied for its varied roles in cancer
development since its initial characterization as a potent retroviral oncogene. It is now clear …
development since its initial characterization as a potent retroviral oncogene. It is now clear …
Analysis of expression of nuclear factor κB (NF‐κB) in multiple myeloma: downregulation of NF‐κB induces apoptosis
H Ni, M Ergin, Q Huang, JZ Qin… - British journal of …, 2001 - Wiley Online Library
Nuclear factor‐κB (NF‐κB) is an important transcription factor that regulates survival in many
cells. Activated NF‐κB has been shown to protect some haematopoietic neoplastic cells from …
cells. Activated NF‐κB has been shown to protect some haematopoietic neoplastic cells from …