Calcineurin inhibition causes α2δ-1–mediated tonic activation of synaptic NMDA receptors and pain hypersensitivity
Calcineurin inhibitors, such as tacrolimus (FK506) and cyclosporine, are widely used as
standard immunosuppressants in organ transplantation recipients. However, these drugs …
standard immunosuppressants in organ transplantation recipients. However, these drugs …
Calcineurin regulates synaptic plasticity and nociceptive transmission at the spinal cord level
Calcineurin, the predominant Ca2+/calmodulin-dependent serine/threonine protein
phosphatase (also known as protein phosphatase 2B), is highly expressed in immune T …
phosphatase (also known as protein phosphatase 2B), is highly expressed in immune T …
[HTML][HTML] Targeting Anti-Inflammatory Pathways to Treat Diabetes-Induced Neuropathy by 6-Hydroxyflavanone
It is evident that inflammation and metabolic syndrome instigated by diabetes mellitus can
precipitate diabetes-induced neuropathy (DIN) and pain. In order to find an effective …
precipitate diabetes-induced neuropathy (DIN) and pain. In order to find an effective …
Mechanism of analgesia by gabapentinoid drugs: Involvement of modulation of synaptogenesis and trafficking of glutamate-gated ion channels
G Varadi - Journal of Pharmacology and Experimental …, 2024 - ASPET
Gabapentinoids have clinically been used for treating epilepsy, neuropathic pain, and
several other neurologic disorders for> 30 years; however, the definitive molecular …
several other neurologic disorders for> 30 years; however, the definitive molecular …
α2δ-1–Bound N-Methyl-d-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents
Abstract Editor's Perspective What We Already Know about This Topic Presynaptic N-methyl-
d-aspartate receptors contribute to opioid tolerance and hyperalgesia as well as neuropathic …
d-aspartate receptors contribute to opioid tolerance and hyperalgesia as well as neuropathic …
Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease
W Xiong, SR Chen, L He, K Cheng, YL Zhao… - Nature …, 2014 - nature.com
Although postsynaptic glycine receptors (GlyRs) as αβ heteromers attract considerable
research attention, little is known about the role of presynaptic GlyRs, likely α homomers, in …
research attention, little is known about the role of presynaptic GlyRs, likely α homomers, in …
[HTML][HTML] Calpain fosters the hyperexcitability of motoneurons after spinal cord injury and leads to spasticity
V Plantier, I Sanchez-Brualla, N Dingu, C Brocard… - Elife, 2019 - elifesciences.org
Up-regulation of the persistent sodium current (I NaP) and down-regulation of the
potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). We here …
potassium/chloride extruder KCC2 lead to spasticity after spinal cord injury (SCI). We here …
Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2–mediated chloride extrusion in peripheral …
Peripheral neuropathic pain, typified by the development of spontaneous pain or pain
hypersensitivity following injury to the peripheral nervous system, is common, greatly impairs …
hypersensitivity following injury to the peripheral nervous system, is common, greatly impairs …
Regulating nociceptive transmission by VG luT2‐expressing spinal dorsal horn neurons
L Wang, SR Chen, H Ma, H Chen… - Journal of …, 2018 - Wiley Online Library
Vesicular glutamate transporter‐2 (VG luT2) mediates the uptake of glutamate into synaptic
vesicles in neurons. Spinal cord dorsal horn interneurons are highly heterogeneous and …
vesicles in neurons. Spinal cord dorsal horn interneurons are highly heterogeneous and …
Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury
Increased N-methyl-d-aspartate receptor (NMDAR) activity and phosphorylation in the spinal
cord are critically involved in the synaptic plasticity and central sensitization associated with …
cord are critically involved in the synaptic plasticity and central sensitization associated with …