[HTML][HTML] Proteomics of multiple sclerosis: inherent issues in defining the pathoetiology and identifying (early) biomarkers

MK Sen, MSM Almuslehi, PJ Shortland… - International Journal of …, 2021 - mdpi.com
Multiple Sclerosis (MS) is a demyelinating disease of the human central nervous system
having an unconfirmed pathoetiology. Although animal models are used to mimic the …

Genomic, proteomic, and systems biology approaches in biomarker discovery for multiple sclerosis

CC Huizar, I Raphael, TG Forsthuber - Cellular immunology, 2020 - Elsevier
Multiple sclerosis (MS) is a neuroinflammatory disorder characterized by autoimmune-
mediated inflammatory lesions in CNS leading to myelin damage and axonal loss. MS is a …

[HTML][HTML] Histological and top-down proteomic analyses of the visual pathway in the cuprizone demyelination model

MSM Almuslehi, MK Sen, PJ Shortland… - Journal of Molecular …, 2022 - Springer
A change in visual perception is a frequent early symptom of multiple sclerosis (MS), the
pathoaetiology of which remains unclear. Following a slow demyelination process caused …

[HTML][HTML] TNFR2 limits proinflammatory astrocyte functions during EAE induced by pathogenic DR2b-restricted T cells

I Raphael, F Gomez-Rivera, RA Raphael… - JCI insight, 2019 - ncbi.nlm.nih.gov
Multiple sclerosis (MS) is an autoimmune neuroinflammatory disease where the underlying
mechanisms driving disease progression have remained unresolved. HLA-DR2b (DRB1 …

[HTML][HTML] Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico …

S Alshamrani, MM Mashraqi, A Alzamami, NA Alturki… - Microorganisms, 2023 - mdpi.com
Molecular mimicry, a phenomenon in which microbial or environmental antigens resemble
host antigens, has been proposed as a potential trigger for autoimmune responses. In this …

[HTML][HTML] Synaptic pathology in multiple sclerosis: a role for Nogo-A signaling in astrocytes?

S Espírito-Santo, VG Coutinho… - Neural Regeneration …, 2023 - journals.lww.com
Multiple sclerosis (MS) is characterized as an inflammatory demyelinating disease that
affects the central nervous system (CNS), leading to sensory, motor and cognitive …

[图书][B] Glutamate and neuropsychiatric disorders: current and emerging treatments

ZM Pavlovic - 2022 - books.google.com
This volume provides a comprehensive overview of recent advances in targeting glutamate
signaling for the treatment of major psychiatric and neurological disorders. It draws on the …

Glutamate in multiple sclerosis: From pathophysiology to treatments

A Pittaluga, G Olivero - Glutamate and neuropsychiatric disorders: Current …, 2022 - Springer
Multiple sclerosis (MS) is an autoimmune disease typified by overt demyelination and
inflammation that develop in selected regions of the central nervous system (CNS). Besides …

多发性硬化症的突触病理学: Nogo-A 信号在星形胶质细胞中的作用?

S Espírito-Santo, VG Coutinho… - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
Multiple sclerosis (MS) is characterized as an inflammatory demyelinating disease that
affects the central nervous system (CNS), leading to sensory, motor and cognitive …

Elucidating the Mechanism of Action of the Novel Remyelination Therapy Nefiracetam

L Mc Donnell - 2022 - researchrepository.ucd.ie
Multiple sclerosis (MS) is a progressive neurodegenerative disorder which occurs when
autoreactive T-lymphocytes infiltrate the central nervous system (CNS) and damage the …