Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

Immuno-positron emission tomography (immunoPET) with 89Zr-labeled antibodies has
shown great potential in cancer imaging. It can provide important information about the …

This review covers recent advances in the use of the squaramide moiety in chemical
research. We focus on the varied applications of squaramides under the broad headings of …

This continuing educational review provides an overview on radiometals used for PET.
General aspects of radiometal-based radiotracers are covered, and the most frequently …

Purpose Almost all radiolabellings of antibodies with 89 Zr currently employ the hexadentate
chelator desferrioxamine (DFO). However, DFO can lead to unwanted uptake of 89 Zr in …

Background Fibroblast activation protein (FAP) is a proline selective serine protease that is
overexpressed in tumor stroma and in lesions of many other diseases that are characterized …

Inert and stable radiolabeling of monoclonal antibodies (mAb), antibody fragments, or
antibody mimetics with radiometals is a prerequisite for immuno-PET. While radiolabeling is …

The use of 89Zr-antibody PET imaging to measure antibody biodistribution and tissue
pharmacokinetics is well established, but current PET systems lack the sensitivity needed to …

The interest in zirconium-89 (89Zr) as a positron-emitting radionuclide has grown
considerably over the last decade due to its standardized production, long half-life of 78.2 h …