Tumor targeted alpha particle therapy with an actinium-225 labelled antibody for carbonic anhydrase IX
KA Morgan, CW Wichmann, LD Osellame, Z Cao… - Chemical …, 2024 - pubs.rsc.org
Selective antibody targeted delivery of α particle emitting actinium-225 to tumors has
significant therapeutic potential. This work highlights the design and synthesis of a new …
significant therapeutic potential. This work highlights the design and synthesis of a new …
Siderophores and iron transport
R Codd - Siderophores and iron transport, 2023 - ses.library.usyd.edu.au
Siderophores are low-molecular-weight organic compounds produced by bacteria and fungi
for Fe (III) supply. Bacteria and fungi biosynthesize siderophores in response to low iron …
for Fe (III) supply. Bacteria and fungi biosynthesize siderophores in response to low iron …
A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements
A covalent adduct of DFOB and DOTA separated by a L-lysine residue (DFOB-L-Lys-N6-
DOTA) exhibited remarkable regioselective metal binding, with {1H}-13C NMR spectral …
DOTA) exhibited remarkable regioselective metal binding, with {1H}-13C NMR spectral …
Improved access to linear tetrameric hydroxamic acids with potential as radiochemical ligands for zirconium (IV)-89 PET imaging
CJM Brown, MP Gotsbacher… - Australian Journal of …, 2020 - CSIRO Publishing
Two new linear tetrameric hydroxamic acid ligands (3 and 4) have been prepared as
potential radioligands for immunological ZrIV-89 positron emission tomography (PET) …
potential radioligands for immunological ZrIV-89 positron emission tomography (PET) …
Moving Beyond Isothiocyanates: A Look at the Stability of Conjugation Links Toward Radiolysis in 89Zr-Labeled Immunoconjugates
R Vizier, P Adumeau, M Moreau… - Bioconjugate …, 2024 - ACS Publications
Zirconium-89 is the most widely used radioisotope for immunoPET because its physical half-
life (78.2 h) suits the one of antibodies. Desferrioxamine B (DFO) is the standard chelator for …
life (78.2 h) suits the one of antibodies. Desferrioxamine B (DFO) is the standard chelator for …
Comparison of the tissue distribution of a long-circulating glucagon-like Peptide-1 agonist determined by positron emission tomography and quantitative whole-body …
EFA Fernandes, J Wilbs, R Raavé… - ACS Pharmacology & …, 2022 - ACS Publications
Positron emission tomography (PET) is a molecular imaging modality that enables non-
invasive visualization of tracer distribution and pharmacology. Recently, peptides with long …
invasive visualization of tracer distribution and pharmacology. Recently, peptides with long …
Evaluation of macrocyclic hydroxyisophthalamide ligands as chelators for zirconium-89
The development of bifunctional chelators (BFCs) for zirconium-89 immuno-PET
applications is an area of active research. Herein we report the synthesis and evaluation of …
applications is an area of active research. Herein we report the synthesis and evaluation of …
Kinetic Analysis and Mechanism of the Hydrolytic Degradation of Squaramides and Squaramic Acids
M Ximenis, E Bustelo, AG Algarra, M Vega… - The Journal of …, 2017 - ACS Publications
The hydrolytic degradation of squaramides and squaramic acids, the product of partial
hydrolysis of squaramides, has been evaluated by UV spectroscopy at 37° C in the pH …
hydrolysis of squaramides, has been evaluated by UV spectroscopy at 37° C in the pH …
Imaging Somatostatin Positive Tumors with Tyr3-Octreotate/Octreotide Conjugated to Desferrioxamine B Squaramide Radiolabeled with either Zirconium-89 or …
Radiolabeled derivatives of Tyr3-octreotide and Tyr3-octreotate, synthetic analogues of the
peptide hormone somatostatin, can be used for positron emission tomography (PET) …
peptide hormone somatostatin, can be used for positron emission tomography (PET) …
Improved non-invasive positron emission tomographic imaging of chemotherapy-induced tumor cell death using Zirconium-89-labeled APOMAB®
Purpose The chimeric monoclonal antibody (mAb) chDAB4 (APOMAB®) targets the Lupus
associated (La)/Sjögren Syndrome-B (SSB) antigen, which is over-expressed in tumors but …
associated (La)/Sjögren Syndrome-B (SSB) antigen, which is over-expressed in tumors but …