BACKGROUND: Many children with asthma continue to experience symptoms despite
available therapies. OBJECTIVE: This study evaluated the efficacy and safety of …

Background Treatment guidelines recommend the regular use of inhaled corticosteroids for
patients with mild persistent asthma. We investigated whether the symptom-driven use of a …

Medical Pharmacology & Therapeutics provides all the information medical and healthcare
students need throughout their degree programme and beyond, including for professional …

The delivery of drugs by inhalation is an integral component of asthma and chronic
obstructive pulmonary disease (COPD) management. However, even with effective inhaled …

Background The safe and appropriate use of long-acting beta-agonists (LABAs) for the
treatment of asthma has been widely debated. In two large clinical trials, investigators found …

Catecholamine-stimulated β2-adrenergic receptor (β2AR) signaling via the canonical Gs–
adenylyl cyclase–cAMP–PKA pathway regulates numerous physiological functions …

Pharmacogenetics is being used to develop personalized therapies specific to subjects from
different ethnic or racial groups. To date, pharmacogenetic studies have been primarily …

In recent years, the altitude acclimatization responses elicited by short-term intermittent
exposure to hypoxia have been subject to renewed attention. The main goal of short-term …

Background In asthmatic patients inadequately controlled on inhaled corticosteroids and/or
those with moderate persistent asthma, two main options are recommended: the …

Background The combination of short-acting β 2-agonists and anticholinergics in the
treatment of COPD has been well documented, but data on combination of long-acting …