The natural variant C491T (rs1800088) in ADRB2 gene substitutes Threonine to Isoleucine
at 164th position in β2AR and results in receptor sequestration and altered binding of …

Severe asthma is considered a heterogeneous disease in which a variety of clinical,
physiological and inflammatory markers determine disease severity. Pivotal studies in the …

Objective The goal of asthma management is to achieve optimal asthma control, defined by
the absence of daytime symptoms, nighttime waking, reliever use, functional limitation, and …

Background Patients with severe or difficult-to-treat asthma on guideline-recommended
Steps 4/5/6 therapy have not previously been described. Objective To characterize patients …

The Global Initiative for Asthma (GINA) is an initiative started in the early 1990s to develop
guidelines for asthma diagnosis and management that were applicable to both developed …

Summary Beta‐2‐Adrenergic receptors (β2AR) participate in the physiologic responses of
the lung, including bronchodilation and bronchoprotection, through mechanisms such as …

Concerns regarding the safety of beta-2 agonists have led to revisions of the major asthma
guidelines to better address these issues. Although these updates allow for a combination of …

abstract Asthma and COPD overlap (ACO) is an important clinical phenotype, due to the low-
health-related quality of life (QOL), rapid decline in lung function, frequent exacerbation, and …

В настоящем обзоре обобщаются многочисленные исследования психических
факторов при заболеваниях внутренних органов. Показана роль психического …

Asthma is a heterogeneous disease in which adequate asthma control cannot be achieved
in a substantial proportion despite currently available treatment possibilities. This subgroup …