To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated
by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by …

The superfamily of cyclic nucleotide (cN) phosphodiesterases (PDEs) is comprised of 11
families of enzymes. PDEs break down cAMP and/or cGMP and are major determinants of …

The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …

The nitric oxide (NO) signalling pathway is altered in cardiovascular diseases, including
systemic and pulmonary hypertension, stroke, and atherosclerosis. The vasodilatory …

Cancer surgery while necessary for primary tumor removal, has been shown to induce
immune suppression and promote metastases in preclinical models and human cancer …

Recently identified isocitrate dehydrogenase (IDH) mutations lead to the production of 2-
hydroxyglutarate (2HG), an oncometabolite aberrantly elevated in selected cancers. We …

As the percentage of wives outearning their husbands grows, the traditional social norm of
the male breadwinner is challenged. The upward income comparison of the husband may …

Doxorubicin (Doxo) is a widely used antineoplastic drug which often induces
cardiomyopathy, leading to congestive heart failure through the intramyocardial production …

Acute kidney injury (AKI) is a common clinical problem that still lacks effective treatment.
Phosphodiesterase-5 (PDE5) inhibitors possess anti-apoptotic and anti-oxidant properties …

BACKGROUND It is well established that the pathogenesis of diabetic nephropathy is
associated with abnormalities of renal nitric oxide (NO) generation. Many of the biological …