It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a
series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first …

Abstract Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT
receptors. The role of 5-HT 5A receptor in neuropathic pain has not previously studied. The …

Serotonin 5-HT7 receptor (5-HT7R) has been the subject of intense research efforts
because of its presence in brain areas such as the hippocampus, hypothalamus, and cortex …

Abstract Serotonin (5-hydroxytryptamine, 5-HT) is one of the extracellular messengers
capable of activating the largest number of receptors (17 receptors belonging to seven …

Among receptors mediating serotonin actions in pain control, the 5-HT7R is of special
interest because it is expressed by primary afferent fibers and intrinsic GABAergic and …

The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of
nociceptive messages. Plastic changes in the properties of neuronal networks in the DH …

In humans, spinal cord lesions induce not only major motor and neurovegetative deficits but
also severe neuropathic pain which is mostly resistant to classical analgesics. Better …

The antinociceptive role of spinal 5-HT 5A receptors in rat models of pain along with their
expression was evaluated in the spinal cord and dorsal root ganglion (DRG). Nociception …

The serotonergic system is involved in pathomechanisms of both epilepsy and neuropathic
pain. So far, participation in the epileptogenesis and maintenance of epilepsy was proved …

In the present study we determined the role of spinal 5-hydroxytriptamine (5-HT) and 5-
HT4/6/7 receptors in the long-term secondary mechanical allodynia and hyperalgesia …