A global view of the genetic basis of Alzheimer disease
C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
Metabolomics and lipidomics strategies in modern drug discovery and development
Metabolomics and lipidomics have an increasingly pivotal role in drug discovery and
development. In the context of drug discovery, monitoring changes in the levels or …
development. In the context of drug discovery, monitoring changes in the levels or …
Alzheimer's disease: Significant benefit from the yeast-based models
KK Epremyan, DV Mamaev… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an age-related, multifaceted neurological disorder associated
with accumulation of aggregated proteins (amyloid Aβ and hyperphosphorylated tau), loss of …
with accumulation of aggregated proteins (amyloid Aβ and hyperphosphorylated tau), loss of …
Plasma proteomics unveil novel immune signatures and biomarkers upon SARS-CoV-2 infection
V Urbiola-Salvador, S Lima de Souza… - International Journal of …, 2023 - mdpi.com
Several elements have an impact on COVID-19, including comorbidities, age and sex. To
determine the protein profile changes in peripheral blood caused by a SARS-CoV-2 …
determine the protein profile changes in peripheral blood caused by a SARS-CoV-2 …
ABCA7-Associated Clinical Features and Molecular Mechanisms in Alzheimer's Disease
X Qian, S Chen, X Liu, H Tang - Molecular Neurobiology, 2023 - Springer
Alzheimer's disease (AD) is the most common type of neurodegenerative disease and its
pathogenesis is still unclear. Genetic factors are thought to account for a large proportion of …
pathogenesis is still unclear. Genetic factors are thought to account for a large proportion of …
Common factors among three types of cells aged in mice
The greatest risk factor for the formation of numerous significant chronic disorders is aging.
Understanding the core molecular underpinnings of aging can help to slow down the …
Understanding the core molecular underpinnings of aging can help to slow down the …
Explainable variational autoencoder (E-VAE) model using genome-wide SNPs to predict dementia
Objective Alzheimer's disease (AD) and AD related dementias (ADRD) are complex
multifactorial neurodegenerative diseases. The associations between genetic variants …
multifactorial neurodegenerative diseases. The associations between genetic variants …
The relationship between 11 different polygenic longevity scores, parental lifespan, and disease diagnosis in the UK Biobank
Large-scale genome-wide association studies (GWAS) strongly suggest that most traits and
diseases have a polygenic component. This observation has motivated the development of …
diseases have a polygenic component. This observation has motivated the development of …
Top Alzheimer's disease risk allele frequencies differ in HABS‐HD Mexican‐versus Non‐Hispanic White Americans
INTRODUCTION: Here we evaluate frequencies of the top 10 Alzheimer's disease (AD) risk
alleles for late‐onset AD in Mexican American (MA) and non‐Hispanic White (NHW) …
alleles for late‐onset AD in Mexican American (MA) and non‐Hispanic White (NHW) …
Host Genetic Variants Linked to COVID-19 Neurological Complications and Susceptibility in Young Adults—A Preliminary Analysis
A Kazantseva, R Enikeeva, Z Takhirova… - Journal of Personalized …, 2023 - mdpi.com
To date, multiple efforts have been made to use genome-wide association studies (GWAS)
to untangle the genetic basis for SARS-CoV-2 infection susceptibility and severe COVID-19 …
to untangle the genetic basis for SARS-CoV-2 infection susceptibility and severe COVID-19 …