How were new medicines discovered?

DC Swinney, J Anthony - Nature reviews Drug discovery, 2011 - nature.com
Preclinical strategies that are used to identify potential drug candidates include target-based
screening, phenotypic screening, modification of natural substances and biologic-based …

[HTML][HTML] Designing a broad-spectrum integrative approach for cancer prevention and treatment

KI Block, C Gyllenhaal, L Lowe, A Amedei… - Seminars in cancer …, 2015 - Elsevier
Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

[HTML][HTML] Genital warts: a comprehensive review

VR Yanofsky, RV Patel… - The Journal of clinical and …, 2012 - ncbi.nlm.nih.gov
External genital warts, also known as condylomata acuminata, are extremely common, with
between 500,000 to one million new cases diagnosed each year in the United States alone …

Residues and contaminants in tea and tea infusions: a review

AM Abd El-Aty, JH Choi, MM Rahman… - Food Additives & …, 2014 - Taylor & Francis
Consumers are very aware of contaminants that could pose potential health hazards. Most
people drink tea as an infusion (adding hot water); however, in some countries, including …

Human papillomavirus–related genital disease in the immunocompromised host: Part II

RH Gormley, CL Kovarik - Journal of the American Academy of …, 2012 - Elsevier
Human papillomavirus is responsible for common condyloma acuminata and a number of
premalignant and malignant anogenital lesions. The immunocompromised population is at …

[HTML][HTML] Current view on green tea catechins formulations, their interactions with selected drugs, and prospective applications for various health conditions

M Cerbin-Koczorowska, M Waszyk-Nowaczyk… - Applied Sciences, 2021 - mdpi.com
Green tea extract (GTE) is one of the most popular beverages globally, traditionally prepared
from Camelia sinensis leaves. Therefore, it is beneficial to define the impact of GTE and its …

Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis

J Mader, A Gallo, T Schommartz, W Handke… - Journal of Allergy and …, 2016 - Elsevier
Background Chronic infections with herpes simplex virus (HSV) type 1 are highly prevalent
in populations worldwide and cause recurrent oral lesions in up to 40% of infected subjects …

An overview of human papillomavirus infection for the dermatologist: disease, diagnosis, management, and prevention

M Forcier, N Musacchio - Dermatologic Therapy, 2010 - Wiley Online Library
Genital human papillomavirus (HPV) is a common, usually transient, dermatologic infection
transmitted by genital contact that can cause a variety of anogenital diseases, including …

[HTML][HTML] Going green: the role of the green tea component EGCG in chemoprevention

L Schramm - Journal of carcinogenesis & mutagenesis, 2013 - ncbi.nlm.nih.gov
Tea is one of the most consumed beverages worldwide, and green tea is the least
processed from the buds of the Camellia sinensis plant. The most abundant component of …

Genital warts and other HPV infections: Established and novel therapies

R Fathi, MM Tsoukas - Clinics in dermatology, 2014 - Elsevier
Wart therapies involve methods of targeted lesion destruction, as well as selective
immunologic modification. While there are several therapeutic options, no treatment has …