Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

The COVID-19 pandemic is an emerging threat to global public health. While our current
understanding of COVID-19 pathogenesis is limited, a better understanding will help us …

Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …

Chemokines are a large family mediating a lot of biological behaviors including chemotaxis,
tumor growth, angiogenesis and so on. As one member of this family, CXC subfamily …

Preclinical mouse models that recapitulate some characteristics of coronavirus disease
(COVID-19) will facilitate focused study of pathogenesis and virus–host responses. Human …

Liver fibrosis could be the last hope for treating liver cancer and remodeling of the hepatic
microenvironment has emerged as a strategy to promote the ablation of liver fibrosis. In …

Liver fibrosis is a process of over‐extracellular matrix (ECM) aggregation and angiogenesis,
which develops into cirrhosis and hepatocellular carcinoma (HCC). With the increasing …

The aryl hydrocarbon receptor (AhR) is a ubiquitously expressed ligand-activated
transcription factor. While initially identified as an environmental sensor, this receptor has …

Intercellular crosstalk among various liver cells plays an important role in liver fibrosis,
cirrhosis, and hepatocellular carcinoma (HCC). Capillarization of liver sinusoidal endothelial …

Pancreatic adenocarcinoma (PAAD) is the 10th most common cancer worldwide and the
outcomes for patients with the disease remain extremely poor. Precision biomarkers are …