Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

During T cell activation, the transmembrane adaptor protein LAT (linker for activation of T
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …

University of Mississippi, University, MS, USA. A challenge within the single molecule
biophysics field is reconstituting a motor-filament environment that reflects physiological …

Cell membranes are composed of a lipid bilayer, containing proteins that span the bilayer
and/or interact with the lipids on either side of the two leaflets. Although recent advances in …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

Cell membranes display a tremendous complexity of lipids and proteins designed to perform
the functions cells require. To coordinate these functions, the membrane is able to laterally …

Signal transduction is initiated by complex protein–protein interactions between ligands,
receptors and kinases, to name only a few. It is now becoming clear that lipid micro …

A growing number of diseases seem to be associated with inappropriate deposition of
protein aggregates. Some of these diseases—such as Alzheimer's disease and systemic …