Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Synaptic activity initiates biochemical processes that have various outcomes, including the
formation of memories, increases in neuronal survival and the development of chronic pain …

Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western
countries. Notably, it has a rapidly rising prevalence in China. The patients, commonly …

Epigenetic changes such as DNA methylation act to regulate gene expression in normal
mammalian development. However, promoter hypermethylation also plays a major role in …

Transcriptional downregulation of E-cadherin appears to be an important event in the
progression of various epithelial tumors. SIP1 (ZEB-2) is a Smad-interacting, multi-zinc …

Fibrogenesis is a pathological wound repair process that fails to cease, even when the initial
insult has been removed. Fibroblasts are principal mediators of fibrosis, and fibroblasts from …

The Insulin-like growth factor 2 (Igf2) and H19 genes are imprinted, resulting in silencing of
the maternal and paternal alleles, respectively. This event is dependent upon an imprinted …

Several studies have recently identified strong epigenetic signals related to tobacco
smoking. However, an aspect that did not receive much attention is the evolution of …

DNA methylation is a major control program that modulates gene expression in a plethora of
organisms. Gene silencing through methylation occurs through the activity of DNA …

Dynamic epigenetic modification of the genome occurs during early development of the
mouse. Active demethylation of the paternal genome occurs in the zygote, followed by …