Dynamic epigenetic modification of the genome occurs during early development of the
mouse. Active demethylation of the paternal genome occurs in the zygote, followed by …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Inactivation of tumour suppressor genes is central to the development of all common forms
of human cancer 1. This inactivation often results from epigenetic silencing associated with …

Genomic imprinting is regulated by differential methylation of the paternal and maternal
genome. However, it remains unknown how parental imprinting is established during …

Early experience permanently alters behavior and physiology. These effects are, in part,
mediated by sustained alterations in gene expression in selected brain regions. The critical …

Gene silencing in eukaryotes is associated with the formation of heterochromatin, a complex
of proteins and DNA that block transcription. Heterochromatin is characterized by the …

MLL, the human homolog of Drosophila trithorax, maintains Hox gene expression in
mammalian embryos and is rearranged in human leukemias resulting in Hox gene …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

Cytosine methylation in CpG dinucleotides is believed to be important in gene regulation,
and is generally associated with reduced levels of transcription. Methylation-mediated gene …