We have previously shown that the DNA methyltransferases Dnmt3a and Dnmt3b carry out
de novo methylation of the mouse genome during early postimplantation development and …

Histone deacetylase (HDAC) inhibitors have been shown to be potent inducers of growth
arrest, differentiation, and/or apoptotic cell death of transformed cells in vitro and in vivo. One …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

Temperature profoundly influences physiological responses in animals, primarily due to the
effects on biochemical reaction rates. Since physiological responses are often exemplified …

DNA methylation can contribute to transcriptional silencing through several transcriptionally
repressive complexes, which include methyl-CpG binding domain proteins (MBDs) and …

Mammalian gene silencing is established through methylation of histones and DNA,
although the order in which these modifications occur remains contentious. Using the …

Knowledge on heritable changes in gene expression that result from epigenetic events is of
increasing relevance in the development of strategies for prevention, early diagnosis and …

DNA methylation, an essential epigenetic feature of DNA that modulates gene expression
and genomic integrity, is catalyzed by methyltransferases that use the universal methyl …

Mouse embryos undergo genome-wide methylation reprogramming by demethylation in
early preimplantation development, followed by remethylation thereafter. Here we show that …

Environmental effects on the materno–foetal interaction determine birth outcomes that
predict health over the lifespan. Thus, maternal undernutrition or stress associate with low …