Variations in maternal behavior are associated with differences in estrogen receptor (ER)-α
expression in the medial preoptic area (MPOA) and are transmitted across generations such …

Cytosine methylation of mammalian DNA is essential for the proper epigenetic regulation of
gene expression and maintenance of genomic integrity. To define the mechanism through …

DNA methylation of tumor suppressor genes is a frequent mechanism of transcriptional
silencing in cancer. The molecular mechanisms underlying the specificity of methylation are …

Metastatic melanoma is a deadly cancer that fails to respond to conventional chemotherapy
and is poorly understood at the molecular level. p53 mutations often occur in aggressive and …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T
cells of infected persons treated with highly active antiretroviral therapy (HAART). This …

It is widely acknowledged that the nature of the maternal care a child receives can have long-
term repercussions, and that children raised in deprived environments can have severe …

Astrocyte differentiation, which occurs late in brain development, is largely dependent on the
activation of a transcription factor, STAT3. We show that astrocytes, as judged by glial …

Mutations in the MECP2 gene cause Rett syndrome (RTT). Bdnf is a MeCP2 target gene;
however, its role in RTT pathogenesis is unknown. We examined Bdnf conditional mutant …

Epigenetic treatment has been approved by regulatory agencies for haematological
malignancies. The success observed in cutaneous lymphomas represents a proof of …