Atherosclerosis, which is the most common chronic disease of the coronary artery,
constitutes a vascular pathology induced by inflammation and plaque accumulation within …

Epigenetic treatment has been approved by regulatory agencies for haematological
malignancies. The success observed in cutaneous lymphomas represents a proof of …

Human immunodeficiency virus type 1 (HIV-1) persists in a latent state within resting CD4+ T
cells of infected persons treated with highly active antiretroviral therapy (HAART). This …

Methylation of cytosines within the CpG dinucleotide by DNA methyltransferases is involved
in regulating transcription and chromatin structure, controlling the spread of parasitic …

Although the field of genetics has grown by leaps and bounds within the last decade due to
the completion and availability of the human genome sequence, transcriptional regulation …

When maize seedlings were exposed to cold stress, a genome-wide demethylation occurred
in root tissues. Screening of genomic DNA identified one particular fragment that was …

Abstract Twenty AdoMet-dependent methyltransferases (MTases) have been characterized
structurally by X-ray crystallography and NMR. These include seven DNA MTases, five RNA …

Determining the effect of DNA methylation on chromatin structure and function in higher
organisms is challenging due to the extreme complexity of epigenetic regulation. We studied …

Recurrence of advanced melanoma after therapy is a major risk factor for reduced survival,
and treatment options are limited. Antitumor immune memory plays a critical role in …

MBD2 and MBD3 are closely related proteins with consensus methyl-CpG binding domains.
MBD2 is a transcriptional repressor that specifically binds to methylated DNA and is a …