Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

Postmenopausal osteoporosis (PMOP) is a prevalent skeletal disorder associated with
menopause-related estrogen withdrawal. PMOP is characterized by low bone mass …

Aged bone marrow mesenchymal stem cells (BMSCs) exhibit aberrant self-renewal and
lineage specification, which contribute to imbalanced bone-fat and progressive bone loss. In …

Bone regeneration is a complex process that requires the coordination of osteogenesis and
osteoclastogenesis. The balance between osteogenesis and adipogenesis of bone marrow …

Background As common progenitor cells of osteoblasts and adipocytes, bone marrow
mesenchymal (stromal) stem cells (BMSCs) play key roles in bone homeostasis, tissue …

Bone is a complex endocrine organ that facilitates structural support, protection to vital
organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow …

Osteoporosis is characterized by a decrease in bone mass and strength, rendering people
prone to osteoporotic fractures caused by low-energy forces. The primary treatment strategy …

There is a complex interaction between titanium dental implants, bone, and the immune
system. Among them, specific immune cells, macrophages play a crucial role in the …

Ongoing research has highlighted the significance of the cross-play of macrophages and
mesenchymal stem cells (MSCs). Lysine-specific demethylase 6B (KDM6B) has been …

Highlights•Cellular senescence drives age-related decline of the musculoskeletal
system.•The Senescence Associated Secretory Phenotype (SASP) can chronically impair …