Aging is associated with a function decline in tissue homeostasis and tissue repair. Aging is
also associated with an increased incidence in osteopenia and osteoporosis, but whether …

Highlights•Cellular senescence drives age-related decline of the musculoskeletal
system.•The Senescence Associated Secretory Phenotype (SASP) can chronically impair …

Osteoporosis is a common age-related disorder characterized by low bone mass and
deterioration in bone microarchitecture, leading to increased skeletal fragility and fracture …

Mesenchymal stem cells (MSCs) are multipotent stromal cells that are identified by in vitro
plastic adherence, colony-forming capacity, expression of a panel of surface molecules, and …

Age-related skeletal degeneration in patients with osteoporosis is characterized by
decreased bone mass and occurs concomitant with an increase in bone marrow adipocytes …

Aberrant lineage commitment of mesenchymal stem cells (MSCs) in marrow contributes to
abnormal bone formation due to reduced osteogenic and increased adipogenic potency …

Mesenchymal stem cells (MSCs) are characterized by their multilineage potential and low
immunogenicity. However, the properties of MSCs under pathological conditions are …

Objectives The use of doxorubicin, an antineoplastic medication used for the treatment of
cancers via mechanisms that prevent replication of cells or lead to their death, can result in …

MSC senescence is considered a contributing factor in aging-related diseases. We
investigated the influence of the inflammatory microenvironment on bone marrow …

Osteoporosis (OP) is characterized by a loss in bone mass and mineral density. The
stimulation of the canonical Wnt/β-catenin pathway has been reported to promote bone …