The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

An industrially feasible approach to overcome the solubility and bioavailability limitations of
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …

Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Moisture plays a critical role in the stability of amorphous solid dispersions (ASD) as it can
lower the glass transition temperature (T g) and thereby increase molecular mobility …

Amorphous solid dispersions (ASDs) are single-phase amorphous systems, where drug
molecules are molecularly dispersed (dissolved) in a polymer matrix. The molecular …

Hot melt extrusion (HME) can be used to produce amorphous solid dispersions (ASDs) at
temperatures below the drug's melting point if the drug and polymer exhibit melting point …

The purpose of this work is to compare the long-term physical stability of amorphous solid
dispersion (ASD) formulations based on three different commercially used excipients …

In this Perspective, the authors examine the various factors that should be considered when
attempting to use miscible amorphous API–excipient mixtures (amorphous solid dispersions …

The evolving challenges associated with the development of poorly soluble drug molecules
have been met with major advances in drug solubilization. In particular, amorphous solid …