Endothelial dysfunction and angiogenesis impairment in the ageing vasculature
Ageing is the main risk factor for the development of cardiovascular diseases. A central
mechanism by which ageing promotes vascular pathologies is compromising endothelial …
mechanism by which ageing promotes vascular pathologies is compromising endothelial …
[HTML][HTML] Age-related impairment of vascular structure and functions
Among age-related diseases, cardiovascular and cerebrovascular diseases are major
causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age …
causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age …
[HTML][HTML] Increase in blood–brain barrier leakage in healthy, older adults
ICM Verheggen, JJA de Jong, MPJ van Boxtel… - Geroscience, 2020 - Springer
Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …
[HTML][HTML] Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
Ultrasound treatment of neurological diseases—current and emerging applications
Like cardiovascular disease and cancer, neurological disorders present an increasing
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
challenge for an ageing population. Whereas nonpharmacological procedures are routine …
Susac syndrome: challenges in the diagnosis and treatment
M Marrodan, MP Fiol, J Correale - Brain, 2022 - academic.oup.com
Susac syndrome is a disorder thought to be mediated by an autoimmune response towards
endothelial cells, leading to a characteristic clinical triad of encephalopathy, visual …
endothelial cells, leading to a characteristic clinical triad of encephalopathy, visual …
Heterogeneity of the blood-brain barrier
The brain microvascular network is comprised of capillaries, arterioles and venules, all of
which retain–although to a different extent–blood-brain barrier (BBB) properties. Capillaries …
which retain–although to a different extent–blood-brain barrier (BBB) properties. Capillaries …
Exercise counteracts declining hippocampal function in aging and Alzheimer's disease
KA Intlekofer, CW Cotman - Neurobiology of disease, 2013 - Elsevier
Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most
common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological …
common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological …
[HTML][HTML] Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse
MR Lowerison, NVC Sekaran, W Zhang, Z Dong… - Scientific reports, 2022 - nature.com
Aging-related cognitive decline is an emerging health crisis; however, no established
unifying mechanism has been identified for the cognitive impairments seen in an aging …
unifying mechanism has been identified for the cognitive impairments seen in an aging …
Obesity-induced cognitive impairment in older adults: a microvascular perspective
P Balasubramanian, T Kiss… - American Journal …, 2021 - journals.physiology.org
Over two-thirds of individuals aged 65 and older are obese or overweight in the United
States. Epidemiological data show an association between the degree of adiposity and …
States. Epidemiological data show an association between the degree of adiposity and …