TLRs (Toll-like receptors) are a family of innate immune receptors that induce protective
immune responses against infections. Single-stranded viral RNA and bacterial DNA …

Therapeutic nucleic acids (TNAs) and its precursors are applied to treat several pathologies
and infections. TNA-based therapy has different rationales and mechanisms and can be …

Bacterial DNA and synthetic oligomers containing CpG dinucleotides activate the immune
system through Toll-like receptor (TLR) 9. Here, we compare the immunostimulatory activity …

The objective of cancer immunotherapy is to prime the host's immune system to recognize
and attack malignant tumor cells. IMO‑2125, a Toll‑like receptor 9 (TLR9) agonist, exhibited …

Mammalian cells express a variety of nucleic acid sensors as one of the first lines of defense
against infection. Despite extensive progress in the study of sensor signaling pathways …

WEIKWRHPSBSLNX-UHFFFAOYSA-N [5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxyoxolan-2-
yl] methyl [5-(4-amino-2-oxopyrimidin-1-yl)-2-(phosphonooxymethyl) oxolan-3-yl] hydrogen …

Unmethylated CpG dinucleotides present within certain specific sequence contexts in
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …

Oligodeoxynucleotides (ODNs) containing unmethylated CpG dinucleotides act as agonists
of TLR9 and induce Th1-type immune responses. In the present study, we synthesized CpG …

Bacterial and synthetic DNAs containing CpG dinucleotides in specific sequence contexts
activate the vertebrate immune system through Toll-like receptor 9 (TLR9). In the present …

The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of
TLRs and methods of use thereof. These IROs have unique sequences that inhibit or …