[HTML][HTML] Emerging functions of human IFIT proteins in cancer
Interferon-induced protein with tetratricopeptide repeats (IFIT) genes are prominent
interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes …
interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes …
[HTML][HTML] A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling
X Zheng, L Chen, Y Zhou, Q Wang, Z Zheng, B Xu… - Molecular cancer, 2019 - Springer
Background It has been well established that circular RNAs (circRNAs) play an important
regulatory role during tumor progression. Recent studies have indicated that even though …
regulatory role during tumor progression. Recent studies have indicated that even though …
[HTML][HTML] The methyltransferase METTL3 promotes tumorigenesis via mediating HHLA2 mRNA m6A modification in human renal cell carcinoma
D Zhu, Y Liu, J Chen, Q Wang, Y Li, Y Zhu… - Journal of translational …, 2022 - Springer
Background As an important N6-methyladenosine (m6A) regulator, abnormal expression of
methyltransferase-like protein 3 (METTL3) has been reported in certain human cancers …
methyltransferase-like protein 3 (METTL3) has been reported in certain human cancers …
[HTML][HTML] Baicalein suppresses stem cell-like characteristics in radio-and chemoresistant MDA-MB-231 human breast cancer cells through up-regulation of IFIT2
Resistance to both chemotherapy and radiation therapy is frequent in triple-negative breast
cancer (TNBC) patients. We established treatment-resistant TNBC MDA-MB-231/IR cells by …
cancer (TNBC) patients. We established treatment-resistant TNBC MDA-MB-231/IR cells by …
[HTML][HTML] Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients
L Chen, D Zhu, J Feng, Y Zhou, Q Wang, H Feng… - Cancer cell …, 2019 - Springer
Background It is well known that human clear cell renal cell carcinoma (ccRCC) is a highly
immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune …
immunogenic and chemo-resistant tumor. Recently, emerging data suggest that the immune …
[HTML][HTML] IFN-lambda 3 mediates antiviral protection against porcine epidemic diarrhea virus by inducing a distinct antiviral transcript profile in porcine intestinal …
L Li, M Xue, F Fu, L Yin, L Feng, P Liu - Frontiers in Immunology, 2019 - frontiersin.org
Type III interferon-lambda (IFN-λ) plays a critical role against infection, particularly in
mucosal infection in the respiratory and gastrointestinal tract. Our study and other previous …
mucosal infection in the respiratory and gastrointestinal tract. Our study and other previous …
[HTML][HTML] Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients
H Deng, H Shi, L Chen, Y Zhou, J Jiang - Cancer Cell International, 2019 - Springer
Background Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is specifically
expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is …
expressed in the embryo and placenta. Recent studies have reported that the Nectin-4 is …
Ifit2 restricts murine coronavirus spread to the spinal cord white matter and its associated myelin pathology
M Sharma, D Chakravarty, A Hussain… - Journal of …, 2023 - Am Soc Microbiol
Interferon-induced protein with tetratricopeptide repeats 2, Ifit2, is critical in restricting
neurotropic murine-β-coronavirus, RSA59 infection. RSA59 intracranial injection of Ifit2 …
neurotropic murine-β-coronavirus, RSA59 infection. RSA59 intracranial injection of Ifit2 …
[HTML][HTML] Bioactive glass selectively promotes cytotoxicity towards giant cell tumor of bone derived neoplastic stromal cells and induces MAPK signalling dependent …
J Fellenberg, S Losch, B Lehner, M Arango-Ospina… - Bioactive Materials, 2022 - Elsevier
Giant cell tumors of bone (GCTB) are associated with massive bone destructions and high
recurrence rates. In a previous study, we observed cytotoxic effects of three different …
recurrence rates. In a previous study, we observed cytotoxic effects of three different …
[HTML][HTML] The Impact of Innate Components on Viral Pathogenesis in the Neurotropic Coronavirus Encephalomyelitis Mouse Model
BT Boylan, M Hwang, CC Bergmann - Viruses, 2023 - mdpi.com
Recognition of viruses invading the central nervous system (CNS) by pattern recognition
receptors (PRRs) is crucial to elicit early innate responses that stem dissemination. These …
receptors (PRRs) is crucial to elicit early innate responses that stem dissemination. These …