Decitabine dosing schedules
HM Kantarjian, JPJ Issa - Seminars in hematology, 2005 - Elsevier
5-Aza-2′-deoxycytidine (decitabine; Dacogen™, MGI Pharma, Inc, Bloomington, MN) is a
cytidine analog that inhibits DNA methyltransferases resulting in loss of DNA methylation …
cytidine analog that inhibits DNA methyltransferases resulting in loss of DNA methylation …
Role of epigenetic changes in hematological malignancies
U Lehmann, K Brakensiek, H Kreipe - Annals of hematology, 2004 - Springer
Inactivation of tumor suppressor genes is an important event contributing to the development
of neoplasia. In addition to the classic genetic mechanisms of deletion or inactivating point …
of neoplasia. In addition to the classic genetic mechanisms of deletion or inactivating point …
Pharmacokinetic evaluation of decitabine for the treatment of leukemia
J Bryan, H Kantarjian, G Garcia-Manero… - Expert Opinion On …, 2011 - Taylor & Francis
Introduction: Acute myeloid leukemia (AML) is a life-threatening malignancy that primarily
afflicts an elderly population. Treatment of elderly patients with intensive chemotherapy is …
afflicts an elderly population. Treatment of elderly patients with intensive chemotherapy is …
Enzymatic regional methylation assay: a novel method to quantify regional CpG methylation density
O Galm, MR Rountree, KE Bachman, KW Jair… - Genome …, 2002 - genome.cshlp.org
We have developed a novel quantitative method for rapidly assessing the CpG methylation
density of a DNA region in mammalian cells. After bisulfite modification of genomic DNA, the …
density of a DNA region in mammalian cells. After bisulfite modification of genomic DNA, the …
Inhibition of HhaI DNA (Cytosine-C5) methyltransferase by oligodeoxyribonucleotides containing 5-aza-2′-deoxycytidine: examination of the intertwined roles of co …
AS Brank, R Eritja, RG Garcia, VE Marquez… - Journal of molecular …, 2002 - Elsevier
The presence of 5-azacytosine (ZCyt) residues in DNA leads to potent inhibition of DNA
(cytosine-C5) methyltranferases (C5-MTases) in vivo and in vitro. Enzymatic methylation of …
(cytosine-C5) methyltranferases (C5-MTases) in vivo and in vitro. Enzymatic methylation of …
New agents in acute myeloid leukemia and other myeloid disorders
F Ravandi, H Kantarjian, F Giles, J Cortes - Cancer, 2004 - Wiley Online Library
Over the past several decades, improvements in chemotherapeutic agents and supportive
care have resulted in significant progress in treating patients with acute myeloid leukemia …
care have resulted in significant progress in treating patients with acute myeloid leukemia …
5-Aza-2′-deoxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel by decreasing LEF1/phospho-β-catenin expression
D Shang, Y Liu, X Xu, T Han, Y Tian - Cancer letters, 2011 - Elsevier
We investigated the molecular mechanisms by which 5-aza-2′-deoxycytidine (DAC) and
paclitaxel (PTX) use lymphoid enhancer-binding factor 1 (LEF1) and the Wnt/β-catenin …
paclitaxel (PTX) use lymphoid enhancer-binding factor 1 (LEF1) and the Wnt/β-catenin …
[图书][B] DNA methylation: approaches, methods, and applications
M Esteller - 2004 - taylorfrancis.com
DNA Methylation: Approaches, Methods and Applications describes the relation DNA
methylation has to gene silencing in disease, and explores its promising role in treating …
methylation has to gene silencing in disease, and explores its promising role in treating …