DNA hypomethylation in certain genes is associated with tobacco exposure but it is
unknown whether these methylation changes translate into increased lung cancer risk. In an …

The epigenome has been heralded as a key'missing piece'of the aetiological puzzle for
complex phenotypes across the biomedical sciences. The standard research approaches …

A single cytosine–guanine dinucleotide (CpG) site within coagulation factor II (thrombin)
receptor-like 3 (F2RL3) was recently found to be hypomethylated in peripheral blood …

Epidemiological studies have demonstrated that genetic, environmental, behavioral, and
clinical factors contribute to cardiovascular disease development. How these risk factors …

Tobacco smoke and nicotine exposure during prenatal and postnatal life can impair lung
development, alter the immune response to viral infections, and increase the prevalence of …

Air pollution of anthropogenic origin is largely from the combustion of biomass (eg, wood),
fossil fuels (eg, cars and trucks), incinerators, landfills, agricultural activities and tobacco …

Monozygotic (MZ) twins share nearly all of their genetic variants and many similar
environments before and after birth. However, they can also show phenotypic discordance …

Advances in laboratory sciences offer much in the challenge to unravel the complex etiology
of cancer and to therefore provide an evidence‐base for prevention. One area where …

Rationale and objectives Self-reported smoking underestimates disease risk. Smoking
affects DNA methylation, in particular the cg05575921 site in the aryl hydrocarbon receptor …

Background: Maternal smoking during pregnancy is associated with significant infant
morbidity and mortality, and may influence later disease risk. One mechanism by which …