Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …

Abstract Background Traditional Chinese medicine (TCM) prescriptions have multiple
bioactive properties.“Gui Zhi–Shao Yao” herb pair is widely used to treat chronic pain (CP) …

Rett syndrome is a neurodevelopmental disorder caused by loss-of-function mutations in the
methyl-CpG binding protein-2 (MeCP2) gene that is characterized by epilepsy, intellectual …

Background Changes in the expression and activity of the AKT oncogene play an important
role in psychiatric disease. We present translational data assessing the role of AKT in …

According to the Research Domain Criteria (RDoC), phenotypic differences among
disorders may be explained by variations in the nature and degree of neural circuitry …

Alzheimer's disease (AD) is usually manifested in patients with dementia, accompanied by
anxiety and other mental symptoms. Emerging evidence from humans indicates that people …

Integrative methods, like colocalization and transcriptome-wide association studies (TWAS),
identify transcriptomic mechanisms at only a fraction of trait-associated genetic loci from …

Phosphorylation by serine-threonine and tyrosine kinases is critical for determining protein
function. Array-based platforms for measuring reporter peptide signal levels allow for …

Background Ketamine (KET) is administered to manage major depression in adolescent
patients. However, the long-term effects of juvenile KET exposure on memory-related tasks …

Introduction: Rapid effects of estrogens within the hippocampus of rodents are dependent
upon cell-signaling cascades, and activation of these cascades by estrogens varies by sex …