Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …
has been one of the most significant biochemical and pharmacological advancements to …
Distribution of cannabinoid receptors in the central and peripheral nervous system
K Mackie - Cannabinoids, 2005 - Springer
CB 1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of
delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has …
delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has …
Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO …
LF Van Gaal, AM Rissanen, AJ Scheen, O Ziegler… - The Lancet, 2005 - thelancet.com
Background In animal models, cannabinoid-1 receptor (CB 1) blockade produces a lean
phenotype, with resistance to diet-induced obesity and associated dyslipidaemia. We …
phenotype, with resistance to diet-induced obesity and associated dyslipidaemia. We …
Cannabinoids and the gut: new developments and emerging concepts
AA Izzo, KA Sharkey - Pharmacology & therapeutics, 2010 - Elsevier
Cannabis has been used to treat gastrointestinal (GI) conditions that range from enteric
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …
infections and inflammatory conditions to disorders of motility, emesis and abdominal pain …
Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures—a short review
I Svíženská, P Dubový, A Šulcová - Pharmacology Biochemistry and …, 2008 - Elsevier
In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …
Modulation of transmitter release via presynaptic cannabinoid receptors
E Schlicker, M Kathmann - Trends in pharmacological sciences, 2001 - cell.com
Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the
development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In …
development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In …
A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
Recent studies suggest that the endocannabinoid system modulates feeding. Despite the
existence of central mechanisms for the regulation of food intake by endocannabinoids …
existence of central mechanisms for the regulation of food intake by endocannabinoids …
Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing
K Wright, N Rooney, M Feeney, J Tate, D Robertson… - Gastroenterology, 2005 - Elsevier
Background & Aims: Two G-protein—coupled cannabinoid receptors, termed CB1 and CB2,
have been identified and several mammalian enteric nervous systems express CB1 …
have been identified and several mammalian enteric nervous systems express CB1 …
Intracellular molecular targets and signaling pathways involved in antioxidative and neuroprotective effects of cannabinoids in neurodegenerative conditions
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …
cannabinoids have received growing interest as treatment options in neurodegenerative …
Cannabinoids and the gastrointestinal tract
RG Pertwee - Gut, 2001 - gut.bmj.com
The enteric nervous system of several species, including the mouse, rat, guinea pig and
humans, contains cannabinoid CB1receptors that depress gastrointestinal motility, mainly by …
humans, contains cannabinoid CB1receptors that depress gastrointestinal motility, mainly by …