Targeting PI3K/AKT/mTOR signaling pathway in pancreatic cancer: from molecular to clinical aspects

S Stanciu, F Ionita-Radu, C Stefani, D Miricescu… - International journal of …, 2022 - mdpi.com
Although pancreatic cancer (PC) was considered in the past an orphan cancer type due to
its low incidence, it may become in the future one of the leading causes of cancer death …

Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

S Mukherjee, R Patra, P Behzadi, A Masotti… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

[HTML][HTML] Microbiota and lung cancer

T Goto - Seminars in cancer biology, 2022 - Elsevier
Until recently, bacteria have been studied in terms of their roles in infectious diseases and
mainly by using isolation and culture methods. However, in practice, many bacteria existing …

Revolutionizing medicine with toll-like receptors: A path to strengthening cellular immunity

JA Malik, G Kaur, JN Agrewala - International Journal of Biological …, 2023 - Elsevier
Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …

Pancreatic ductal adenocarcinoma and nutrition: Exploring the role of diet and gut health

P Gualtieri, R Cianci, G Frank, E Pizzocaro… - Nutrients, 2023 - mdpi.com
The incidence of pancreatic cancer is increasing worldwide. The most common form is
represented by pancreatic ductal adenocarcinoma (PDAC) which has been shown to be …

The mechanism and progress of ferroptosis in pancreatic cancer

ZH Bao, XB Hou, HL Li, YF Mao, WR Wang - Acta histochemica, 2022 - Elsevier
Pancreatic cancer is one of the deadliest cancers in the world, causing hundreds of
thousands of deaths worldwide annually. Because of late diagnosis, rapid metastasis and …

[HTML][HTML] Ginsenoside Rg1 regulated subpopulation homeostasis of Tfh cells ameliorate experimental colitis by inhibiting TLR/MyD88 pathway

Z Zhang, Q Jiang, L Huang, J Huang, Q Wan… - Journal of Functional …, 2024 - Elsevier
The imbalance of follicular helper T (Tfh) cell subset is closely related to the occurrence of
inflammatory bowel disease (IBD). Ginsenoside Rg1 (G-Rg1), the main component of …

Participation of TLRs in cancer immunopathogenesis and drug resistance via interacting with immunological and/or non-immunological signaling pathways as well as …

S Alhajlah - International Immunopharmacology, 2024 - Elsevier
Toll-like receptors (TLRs) have a convoluted role in cancer even though they are crucial to
the immune system. By bridging the innate immune system and cancer, TLRs have a very …

NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family

F Donnarumma, V Tucci, C Ambrosino, L Altucci… - Clinical …, 2022 - Springer
Chromatin structural organization, gene expression and proteostasis are intricately
regulated in a wide range of biological processes, both physiological and pathological …

Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway

Z Xu, G Zhang, X Zhang, Y Lei, Y Sun, F Yang… - … International Journal of …, 2023 - Elsevier
Neuroinflammation is a common response in various neurological disorders. Mesenchymal
stem cell-based treatment has become a promising therapy for neuroinflammation …