Antifolates are structural analogs of folates, essential one-carbon donors in the synthesis of
DNA in mammalian cells. Antifolates are inhibitors of key enzymes in folate metabolism …

Background The evaluation of the proportional hazards (PH) assumption in survival analysis
is an important issue when Hazard Ratio (HR) is chosen as summary measure. The aim is to …

Background Erlotinib, docetaxel, and pemetrexed are approved for the second-line
treatment of non-small-cell lung cancer (NSCLC), but no head-to-head data from large …

To complement the existing treatment guidelines for all tumour types, ESMO organises
consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO …

Purpose Vandetanib is a once-daily oral inhibitor of vascular endothelial growth factor
receptor and epidermal growth factor receptor signaling. This randomized, placebo …

Purpose Doublet chemotherapy is more effective than single-agent as first-line treatment of
advanced non–small-cell lung cancer (NSCLC). As second-line treatment, several …

Aim: To study the clinical benefits of concurrent metformin and immune checkpoint inhibitors
(ICIs) in non-small-cell lung cancer patients. Materials & methods: This is a retrospective …

Purpose We hypothesized that bevacizumab, a monoclonal antibody against vascular
endothelial growth factor (VEGF), will potentiate the activity of pemetrexed, a multitargeted …

Lung cancer is a leading cause of death among adults. Non-small cell lung cancer (NSCLC)
accounts for∼ 85% of all lung cancer cases. For more than half of all patients diagnosis …

Currently, lung cancer has remained the most common cause of cancer death while non-
small cell lung cancer (NSCLC) accounts for the most of all lung cancer cases. Regardless …