Chlamydia trachomatis vaccines for genital infections: where are we and how far is there to go?

LM de la Maza, TL Darville, S Pal - Expert review of vaccines, 2021 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. Antibiotic treatment does not prevent against reinfection and a …

Chlamydia trachomatis vaccine development – a view on the current challenges and how to move forward

ÁH Borges, F Follmann, J Dietrich - Expert Review of Vaccines, 2022 - Taylor & Francis
Introduction Chlamydia trachomatis is the most common sexually transmitted bacterial
pathogen in the world. A licensed vaccine is not yet available, but the first vaccines have …

[HTML][HTML] Efficacy of a synthetic peptide Chlamydia pecorum major outer membrane protein vaccine in a wild koala (Phascolarctos cinereus) population

SJ Simpson, DP Higgins, P Timms, VSA Mella… - Scientific Reports, 2023 - nature.com
Chlamydiosis is a significant disease affecting Eastern Australian koala (Phascolarctos
cinereus) populations, impacting individual animal welfare and fecundity and therefore …

[HTML][HTML] Th1/Th17 T cell tissue-resident immunity increases protection, but is not required in a vaccine strategy against genital infection with chlamydia trachomatis

NDNT Nguyen, S Guleed, AW Olsen… - Frontiers in …, 2021 - frontiersin.org
The requirement for vaccine-induced tissue-resident immunity for protection against one or
repeated infections with Chlamydia trachomatis (Ct) is still not fully resolved. In this study …

[HTML][HTML] Immune signature of Chlamydia vaccine CTH522/CAF® 01 translates from mouse-to-human and induces durable protection in mice

AW Olsen, I Rosenkrands, CS Jacobsen… - Nature …, 2024 - nature.com
The clinical development of an effective Chlamydia vaccine requires in-depth understanding
of how well protective pre-clinical immune signatures translate to humans. Here, we report a …

[HTML][HTML] Evaluation of Four Adjuvant Combinations, IVAX-1, IVAX-2, CpG-1826+ Montanide ISA 720 VG and CpG-1018+ Montanide ISA 720 VG, for Safety and for …

S Pal, A Slepenkin, J Felgner, D Huw Davies… - Pathogens, 2023 - mdpi.com
There is an urgent need to produce a vaccine for Chlamydia trachomatis infections. Here,
using the Chlamydia muridarum major outer membrane protein (MOMP) as an antigen, four …

[HTML][HTML] DnaJ, a promising vaccine candidate against Ureaplasma urealyticum infection

F Guo, Y Tang, W Zhang, H Yuan, J Xiang… - Applied Microbiology …, 2022 - Springer
Ureaplasma urealyticum (U. urealyticum, Uu) is a common sexually transmitted pathogen
that is responsible for diseases such as non-gonococcal urethritis, chorioamnionitis, and …

Edwardsiella tarda outer membrane protein 1 is a virulence factor and a protective immunogen

C Jin, M Li - Aquaculture, 2021 - Elsevier
The bacterial outer membrane proteins are important components of bacterial cell.
Edwardsiella tarda is a vital bacterial pathogen to a wide range of aquaculture animals. In …

[HTML][HTML] Induction of Protection in Mice against a Chlamydia muridarum Respiratory Challenge by a Vaccine Formulated with the Major Outer Membrane Protein in …

DF Tifrea, W He, S Pal, AC Evans, SF Gilmore… - Vaccines, 2021 - mdpi.com
Chlamydia trachomatis is a sexually transmitted bacterium that infects over 130 million
individuals worldwide annually. To implement a vaccine, we developed a cell-free co …

[HTML][HTML] Recognition of Chlamydia trachomatis by Toll-Like Receptor 9 is altered during persistence

A Diallo, G Overman, P Sah, GW Liechti - bioRxiv, 2024 - ncbi.nlm.nih.gov
Abstract Toll-like receptor 9 (TLR9) is an innate immune receptor that localizes to
endosomes in antigen presenting cells and recognizes single stranded unmethylated CpG …