Language deficits in primary lateral sclerosis: cortical atrophy, white matter degeneration and functional disconnection between cerebral regions
EL Tan, M Tahedl, J Lope, JC Hengeveld… - Journal of …, 2024 - Springer
Background Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …
The involvement of language‐associated networks, tracts, and cortical regions in frontotemporal dementia and amyotrophic lateral sclerosis: Structural and functional …
M Tahedl, EL Tan, RH Chipika, J Lope… - Brain and …, 2023 - Wiley Online Library
Background Language deficits are cardinal manifestations of some frontotemporal dementia
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …
[HTML][HTML] Hippocampal subfield and anterior-posterior segment volumes in patients with sporadic amyotrophic lateral sclerosis
S Liu, Q Ren, G Gong, Y Sun, B Zhao, X Ma… - NeuroImage: Clinical, 2021 - Elsevier
Neuroimaging studies of hippocampal volumes in patients with amyotrophic lateral sclerosis
(ALS) have reported inconsistent results. Our aims were to demonstrate that such …
(ALS) have reported inconsistent results. Our aims were to demonstrate that such …
[HTML][HTML] Selective vulnerability of hippocampal sub-regions in patients with subcortical vascular mild cognitive impairment
J Chen, J Wang, K Duan, X Li, Z Pan, J Zhang… - Brain Imaging and …, 2024 - Springer
Early diagnosis of subcortical vascular mild cognitive impairment (svMCI) is clinically
essential because it is the most reversible subtype of all cognitive impairments. Since …
essential because it is the most reversible subtype of all cognitive impairments. Since …
[HTML][HTML] Harnessing Big Data in Amyotrophic Lateral Sclerosis: Machine Learning Applications for Clinical Practice and Pharmaceutical Trials
EL Tan, J Lope, P Bede - Journal of Integrative Neuroscience, 2024 - imrpress.com
The arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the
dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic …
dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic …
Biomarker development in amyotrophic lateral sclerosis: Challenges and viable strategies.
P Bede, J Lope - European Journal of Neurology, 2022 - search.ebscohost.com
Recently proposed biomarkers in ALS have huge practical potential to ascertain phenotype-
associated molecular or imaging profiles early in the course of the disease, track disease …
associated molecular or imaging profiles early in the course of the disease, track disease …
[HTML][HTML] Imaging data reveal divergent longitudinal trajectories in PLS, ALS and poliomyelitis survivors: Group-level and single-subject traits
Imaging profiles from a longitudinal single-centre motor neuron disease study are
presented. A standardized T1-weighted MRI protocol was implemented to characterise …
presented. A standardized T1-weighted MRI protocol was implemented to characterise …
Association of amyotrophic lateral sclerosis and Alzheimer's disease: New entity or coincidence? A case series
A Vrillon, V Deramecourt, F Pasquier… - Journal of …, 2021 - content.iospress.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical,
genetic, and pathological connection but association of ALS with Alzheimer's disease (AD) …
genetic, and pathological connection but association of ALS with Alzheimer's disease (AD) …
[HTML][HTML] Hippocampal Subregion and Gene Detection in Alzheimer's Disease Based on Genetic Clustering Random Forest
J Li, W Liu, L Cao, H Luo, S Xu, P Bao, X Meng… - Genes, 2021 - mdpi.com
The distinguishable subregions that compose the hippocampus are differently involved in
functions associated with Alzheimer's disease (AD). Thus, the identification of hippocampal …
functions associated with Alzheimer's disease (AD). Thus, the identification of hippocampal …
[PDF][PDF] Open-source hypothalamic-ForniX (OSHy-X) atlases and segmentation tool for 3T and 7T
Segmentation and volumetric analysis of the hypothalamus and fornix plays a critical role in
improving the understanding of degenerative processes that might impact the function of …
improving the understanding of degenerative processes that might impact the function of …