Background Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …

Background Language deficits are cardinal manifestations of some frontotemporal dementia
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …

Neuroimaging studies of hippocampal volumes in patients with amyotrophic lateral sclerosis
(ALS) have reported inconsistent results. Our aims were to demonstrate that such …

Early diagnosis of subcortical vascular mild cognitive impairment (svMCI) is clinically
essential because it is the most reversible subtype of all cognitive impairments. Since …

The arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the
dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic …

Recently proposed biomarkers in ALS have huge practical potential to ascertain phenotype-
associated molecular or imaging profiles early in the course of the disease, track disease …

Imaging profiles from a longitudinal single-centre motor neuron disease study are
presented. A standardized T1-weighted MRI protocol was implemented to characterise …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia have a strong clinical,
genetic, and pathological connection but association of ALS with Alzheimer's disease (AD) …

The distinguishable subregions that compose the hippocampus are differently involved in
functions associated with Alzheimer's disease (AD). Thus, the identification of hippocampal …

Segmentation and volumetric analysis of the hypothalamus and fornix plays a critical role in
improving the understanding of degenerative processes that might impact the function of …