Cariprazine is a new atypical antipsychotic drug (APD) with a unique pharmacodynamic
profile, different from both typical and atypical APDs. Specifically, cariprazine acts as a …

Neurodevelopmental disorders (NDDs) begin in the earliest months of life, but the clinical
manifestations of many such disorders—including intellectual disability, autism spectrum …

Silencing of dopamine transporter (DAT), a main controlling factor of dopaminergic
signaling, results in biochemical and behavioral features characteristic for neuropsychiatric …

Early life stress compromises brain development and can contribute to the development of
mental illnesses. A common animal model used to study different facets of psychiatric …

Dysfunctions of the thyroid hormone (TH) transporting monocarboxylate transporter MCT8
lead to a complex X-linked syndrome with abnormal serum TH concentrations and …

Cognitive functions including social cognition improve significantly during adolescence, the
time period during which the brain typically handles a large volume of incoming information …

Social isolation is a reliable method used for the induction of depression and psychiatric
disorders in rodents. It has been suggested that social isolation can lead to …

Ketamine acts as a rapid clinical antidepressant at 25 min after injection with effects
sustained for 7 days. As dissociative effects emerging acutely after injection are not entirely …

Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent psychiatric
disorders that affects children and even continues into adulthood. Dexmedetomidine (DEX) …

The focus of this paper is the requirement that the use of live animals in experiments and in
vivo assays should never be allowed if those uses involve severe suffering. This …