Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation
syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening …

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …

Context.—Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder of
immune regulation that can eventually result in end-organ damage and death. HLH is …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Severe congenital neutropenias are a heterogeneous group of rare haematological
diseases characterized by impaired maturation of neutrophil granulocytes. Patients with …

Macrophage activation syndrome (MAS) refers to acute overwhelming inflammation caused
by a'cytokine storm'. Although increasingly recognized as a life-threatening complication of …

Lysosomes are highly dynamic organelles that can move rapidly throughout the cell. They
distribute in a rather immobile pool located around the microtubule‐organizing center in a …