Autoimmunity and cancer affect millions worldwide and both, in principal, result from
dysregulated immune responses. There are many well-known molecules involved in …

Patients with coronavirus disease 2019 (COVID-19) have a wide variety of clinical outcomes
ranging from asymptomatic to severe respiratory syndrome that can progress to life …

In the human genome, the aminopeptidases ERAP1, ERAP2 and LNPEP lie contiguously on
chromosome 5. They share sequence homology, functions and associations with immune …

Following influenza infection, rs2248374-G ERAP2 expressing cells may transcribe an
alternative spliced isoform: ERAP2/Iso3. This variant, unlike ERAP2-wt, is unable to trim …

Background: Salt sensitivity of blood pressure (SSBP) is a trait observed in both humans and
animals, characterized by an increase in blood pressure (BP) following salt loading or a …

Background Dietary sodium is a well-known risk factor for cardiovascular and renal disease;
however, direct evidence of the longitudinal changes that occur with aging, and the …

Inconsistencies have been reported on the effect of sex on aldosterone levels leading to
clinical confusion. The reasons for these inconsistencies, are uncertain but include: estrogen …

Antigen (Ag)-trimming aminopeptidases belong to the oxytocinase subfamily of M1
metallopeptidases. In humans, this subfamily contains the endoplasmic reticulum …

BACKGROUND: Salt sensitivity of blood pressure (SSBP) is a substantial risk factor for
cardiovascular morbidity and mortality. Striatin (STRN) is critical for estrogen and …

Dental pain from apical periodontitis is an infection induced-orofacial pain condition that
presents with diversity in pain phenotypes among patients. While 60% of patients with a full …