Systemic sclerosis (SSc) is a severe autoimmune disease that is characterized by vascular
abnormalities, immunological alterations and fibrosis of the skin and internal organs. The …

Background In fibrotic interstitial lung diseases, exertional breathlessness is strongly linked
to health-related quality of life (HRQOL). Breathlessness is often associated with oxygen …

Background Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease with a poor
prognosis. Fibroblasts and myofibroblasts are the key cells in the fibrotic process. Recently …

Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute
exacerbation of idiopathic pulmonary fibrosis is associated with high mortality. Excessive …

Background Observational data under real-life conditions in idiopathic pulmonary fibrosis
(IPF) is scarce. We explored anti-fibrotic treatment, disease severity and phenotypes in …

Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology;
however, apoptosis of lung alveolar epithelial cells plays a role in disease progression. This …

Background Acute respiratory worsening (ARW) requiring hospitalization in patients with
fibrotic interstitial lung disease (f-ILD) is common. Little is known about the frequency and …

Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death.
Underlying biological processes involve induced massive deposition of extracellular matrix …

Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by scattered fibrotic
lesions in the lungs. The pathogenesis and genetic basis of IPF remain poorly understood …

Fibrotic diseases constitute a world-wide major health problem, but research support
remains inadequate in comparison to the need. Although considerable understanding of the …