The genetics and pathogenesis of CAKUT
CM Kolvenbach, S Shril, F Hildebrandt - Nature Reviews Nephrology, 2023 - nature.com
Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …
malformations that arise from defective kidney or urinary tract development and frequently …
The “3Ds” of growing kidney organoids: Advances in nephron development, disease modeling, and drug screening
BE Chambers, NE Weaver, RA Wingert - Cells, 2023 - mdpi.com
A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …
Principles of zebrafish nephron segment development
TK Nguyen, M Petrikas, BE Chambers… - Journal of Developmental …, 2023 - mdpi.com
Nephrons are the functional units which comprise the kidney. Each nephron contains a
number of physiologically unique populations of specialized epithelial cells that are …
number of physiologically unique populations of specialized epithelial cells that are …
The impact of intrauterine growth restriction and prematurity on nephron endowment
MR Sutherland, MJ Black - Nature Reviews Nephrology, 2023 - nature.com
In humans born at term, maximal nephron number is reached by the time nephrogenesis is
completed—at approximately 36 weeks' gestation. The number of nephrons does not …
completed—at approximately 36 weeks' gestation. The number of nephrons does not …
Estrogen signaling influences nephron segmentation of the zebrafish embryonic kidney
HM Wesselman, AE Gatz, MR Pfaff, L Arceri… - Cells, 2023 - mdpi.com
Despite significant advances in understanding nephron segment patterning, many questions
remain about the underlying genes and signaling pathways that orchestrate renal progenitor …
remain about the underlying genes and signaling pathways that orchestrate renal progenitor …
Elucidating the proximal tubule HNF4A gene regulatory network in human kidney organoids
Background The proximal tubule plays a major role in electrolyte homeostasis. Previous
studies have shown that HNF4A regulates reabsorption-related genes and promotes …
studies have shown that HNF4A regulates reabsorption-related genes and promotes …
Kidney Disease Modeling with Organoids and Organs-on-Chips
S Musah, R Bhattacharya… - Annual Review of …, 2024 - annualreviews.org
Kidney disease is a global health crisis affecting more than 850 million people worldwide. In
the United States, annual Medicare expenditures for kidney disease and organ failure …
the United States, annual Medicare expenditures for kidney disease and organ failure …
Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional
units of the kidney. Here, manipulation of p38 and YAP activity allowed for long-term clonal …
units of the kidney. Here, manipulation of p38 and YAP activity allowed for long-term clonal …
(Zebra) fishing for nephrogenesis genes
BE Chambers, NE Weaver, CM Lara, TK Nguyen… - Tissue …, 2024 - Taylor & Francis
Kidney disease is a devastating condition affecting millions of people worldwide, where over
100,000 patients in the United States alone remain waiting for a lifesaving organ transplant …
100,000 patients in the United States alone remain waiting for a lifesaving organ transplant …
Modeling podocyte ontogeny and podocytopathies with the zebrafish
BE Drummond, WS Ercanbrack… - Journal of Developmental …, 2023 - mdpi.com
Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process
of blood filtration. Congenital malformation or damage to podocytes has dire consequences …
of blood filtration. Congenital malformation or damage to podocytes has dire consequences …