The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Simple Summary In the fight against cancer, immunotherapies have given great hope after
encouraging results in clinical investigations showing complete remission in some patients …

The barrier surfaces of the gastrointestinal tract are in constant contact with various
microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the …

Abstract Interleukin-12 (IL-12) is a potent driver of type 1 immunity. Paradoxically, in
autoimmune conditions, including of the CNS, IL-12 reduces inflammation. The underlying …

Autoimmune diseases generally result from the loss of self-tolerance (ie, failure of the
immune system to distinguish self from non-self), and are characterized by autoantibody …

Infections are known to trigger flares of autoimmune diseases in humans and serve as an
inciting cause of autoimmunity in animals. Evidence suggests a causative role of infections …

Multiple sclerosis (MS) is a chronic inflammatory disease that is characterized by leukocyte
infiltration and subsequent axonal damage, demyelinating inflammation, and formation of …

It is difficult to carry out early diagnosis and treatment of Multiple sclerosis (MS) because of
the complex pathogenesis elicited by diversified autoantigens. Monocytes play important …

Autoimmune disease is known to be caused by unregulated self-antigen-specific T cells,
causing tissue damage. Although antigen specificity is an important mechanism of the …

The pathology in neurodegenerative diseases is often accompanied by inflammation. It is
well-known that many cells within the central nervous system (CNS) also contribute to …