Mucins: the frontline defence of the lung

C Ridley, DJ Thornton - Biochemical Society Transactions, 2018 - portlandpress.com
Mucus plays a vital role in protecting the lungs from environmental factors, but conversely, in
muco-obstructive airway disease, mucus becomes pathologic. In its protective role, mucus …

Protein glycosylation: structural and functional aspects

H Lis, N Sharon - European journal of biochemistry, 1993 - Wiley Online Library
During the last decade, there have been enormous advances in our knowledge of
glycoproteins and the stage has been set for the biotechnological production of many of …

O-linked protein glycosylation structure and function

EF Hounsell, MJ Davies, DV Renouf - Glycoconjugate journal, 1996 - Springer
There has been a recent resurgence of interest in the post-translational modification of
serine and threonine hydroxyl groups by glycosylation, because the resulting O-linked …

The Asn‐linked carbohydrate chains of human Tamm‐Horsfall glycoprotein of one male: Novel sulfated and novel N‐acetylgalactosamine‐containing N‐linked …

K Hård, G Van Zadelhoff, P Moonen… - European journal of …, 1992 - Wiley Online Library
Human Tamm‐Horsfall glycoprotein has been purified from the urine of one male. The Asn‐
linked carbohydrate chains were enzymically released by peptide‐N4‐(N‐acetyl‐β …

Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis

G Lamblin, S Degroote, JM Perini, P Delmotte… - Glycoconjugate …, 2001 - Springer
Human airway mucins represent a very broad family of polydisperse high molecular mass
glycoproteins, which are part of the airway innate immunity. Apomucins, which correspond to …

Altered O-glycosylation and sulfation of airway mucins associated with cystic fibrosis

B Xia, JA Royall, G Damera, GP Sachdev… - …, 2005 - academic.oup.com
Cystic fibrosis (CF) is the most lethal genetic disorder in Caucasians and is characterized by
the production of excessive amounts of viscous mucus secretions in the airways of patients …

Bacterial glycosulphatases and sulphomucin degradation

AM Roberton, DP Wright - Canadian Journal of Gastroenterology …, 1997 - hindawi.com
The presence of a high bacterial population in a region of the gastrointestinal tract is usually
associated with the secretion of sulphomucins into the mucus gel covering that region. The …

Molecular Diagnosis of Mycoplasma pneumoniae Respiratory Tract Infections

K Loens, D Ursi, H Goossens… - Journal of clinical …, 2003 - Am Soc Microbiol
Mycoplasma pneumoniae is responsible for 10 to 20% of the cases of community-acquired
pneumonia and has been associated with acute exacerbations of asthma (22). M …

Relevance of nucleic acid amplification techniques for diagnosis of respiratory tract infections in the clinical laboratory

M Ieven, H Goossens - Clinical Microbiology Reviews, 1997 - Am Soc Microbiol
Clinical laboratories are increasingly receiving requests to perform nucleic acid amplification
tests for the detection of a wide variety of infectious agents. In this paper, the efficiency of …

The role of airway mucus in pulmonary toxicology.

JM Samet, PW Cheng - Environmental health perspectives, 1994 - ehp.niehs.nih.gov
Airway mucus is a complex airway secretion whose primary function as part of the
mucociliary transport mechanism is to to serve as renewable and transportable barrier …