Glymphatic system impairment in Alzheimer's disease and idiopathic normal pressure hydrocephalus

BC Reeves, JK Karimy, AJ Kundishora, H Mestre… - Trends in molecular …, 2020 - cell.com
Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus
(iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and …

[HTML][HTML] The glymphatic hypothesis: the theory and the evidence

SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2022 - Springer
The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of
the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there …

Glymphatic MRI in idiopathic normal pressure hydrocephalus

G Ringstad, SAS Vatnehol, PK Eide - Brain, 2017 - academic.oup.com
The glymphatic system has in previous studies been shown as fundamental to clearance of
waste metabolites from the brain interstitial space, and is proposed to be instrumental in …

[HTML][HTML] Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence

SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2014 - Springer
Interstitial fluid (ISF) surrounds the parenchymal cells of the brain and spinal cord while
cerebrospinal fluid (CSF) fills the larger spaces within and around the CNS. Regulation of …

Current concepts in intracranial interstitial fluid transport and the glymphatic system: part II—imaging techniques and clinical applications

JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
The glymphatic system is a recently discovered network unique to the central nervous
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …

[HTML][HTML] The pulsating brain: a review of experimental and clinical studies of intracranial pulsatility

ME Wagshul, PK Eide, JR Madsen - Fluids and Barriers of the CNS, 2011 - Springer
The maintenance of adequate blood flow to the brain is critical for normal brain function;
cerebral blood flow, its regulation and the effect of alteration in this flow with disease have …

The formation of cerebrospinal fluid: nearly a hundred years of interpretations and misinterpretations

D Orešković, M Klarica - Brain research reviews, 2010 - Elsevier
The first scientific and experimental approaches to the study of cerebrospinal fluid (CSF)
formation began almost a hundred years ago. Despite researchers being interested for so …

Current concepts in intracranial interstitial fluid transport and the glymphatic system: part I—anatomy and physiology

JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
Normal physiologic function of organs requires a circulation of interstitial fluid to deliver
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …

Diagnostic performance of glymphatic system evaluation using diffusion tensor imaging in idiopathic normal pressure hydrocephalus and mimickers

H Yokota, A Vijayasarathi, M Cekic… - Current Gerontology …, 2019 - Wiley Online Library
Purpose. To investigate the pathological change of the glymphatic system in idiopathic
normal pressure hydrocephalus (iNPH) using diffusion tensor imaging (DTI) analysis …

Recent insights into a new hydrodynamics of the cerebrospinal fluid

M Bulat, M Klarica - Brain research reviews, 2011 - Elsevier
According to the traditional hypothesis, the cerebrospinal fluid (CSF) is secreted inside the
brain ventricles and flows unidirectionally along subarachnoid spaces to be absorbed into …