The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Abstract Purpose of Review Computational and mathematical modeling have become a
critical part of understanding in-host infectious disease dynamics and predicting effective …

Understanding the decay and maintenance of long-term SARS-CoV-2 neutralizing
antibodies in infected or vaccinated people and how vaccines protect against other SARS …

Plasmodium falciparum gametocytes, the sexual stage responsible for malaria parasite
transmission from humans to mosquitoes, are key targets for malaria elimination. Immature …

Multidrug-resistant Plasmodium falciparum parasites have emerged in Cambodia and
neighboring countries in Southeast Asia, compromising the efficacy of first-line antimalarial …

Malaria is spread by the transmission of sexual stage parasites, called gametocytes.
However, with Plasmodium falciparum, gametocytes can only be detected in peripheral …

Background Artemisinins (ART) are the key component of the frontline antimalarial
treatment, but their impact on Plasmodium falciparum sexual conversion rates in natural …

Malaria transmission is dependent on the formation of gametocytes in the human blood. The
sexual conversion rate, the proportion of asexual parasites that convert into gametocytes at …

Successful infectious disease interventions can result in large reductions in parasite
prevalence. Such demographic change has fitness implications for individual parasites and …

Asexual blood-stage malaria parasites must produce sexual progeny to infect mosquitoes. It
is important to understand the scope and causes of intraspecific variation in sexual …