Inefficiency of medical therapies used in order to cure patients with bacterial infections
requires not only to actively look for new therapeutic strategies but also to carefully select …

The limited armamentarium against drug-resistant Gram-negative bacilli has led to the
development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …

Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …

Objective: The first 70 years of critical care can be considered a period of “industrial
revolution-like” advancement in terms of progressing the understanding and care of critical …

Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis, aiming at
controlling the associated dysregulation of the immune system, which is known to induce …

Background: Emerging data suggest that more aggressive beta-lactam PK/PD targets could
minimize the occurrence of microbiological failure and/or resistance development. This …

Sepsis is a medical emergency and life-threatening condition due to a dysregulated host
response to infection, which is time-dependent and associated with unacceptably high …