[HTML][HTML] The minimum inhibitory concentration of antibiotics: Methods, interpretation, clinical relevance
B Kowalska-Krochmal, R Dudek-Wicher - Pathogens, 2021 - mdpi.com
Inefficiency of medical therapies used in order to cure patients with bacterial infections
requires not only to actively look for new therapeutic strategies but also to carefully select …
requires not only to actively look for new therapeutic strategies but also to carefully select …
New β-lactam–β-lactamase inhibitor combinations
D Yahav, CG Giske, A Grāmatniece… - Clinical microbiology …, 2020 - Am Soc Microbiol
The limited armamentarium against drug-resistant Gram-negative bacilli has led to the
development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this …
development of several novel β-lactam–β-lactamase inhibitor combinations (BLBLIs). In this …
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …
[HTML][HTML] The Japanese clinical practice guidelines for management of sepsis and septic shock 2020 (J-SSCG 2020)
M Egi, H Ogura, T Yatabe, K Atagi, S Inoue, T Iba… - Journal of intensive …, 2021 - Springer
Abstract The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …
Shock 2020 (J-SSCG 2020), a Japanese-specific set of clinical practice guidelines for sepsis …
[HTML][HTML] Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics …
R Guilhaumou, S Benaboud, Y Bennis… - Critical Care, 2019 - Springer
Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …
Nosocomial infection
MH Kollef, A Torres, AF Shorr… - Critical care …, 2021 - journals.lww.com
Objective: The first 70 years of critical care can be considered a period of “industrial
revolution-like” advancement in terms of progressing the understanding and care of critical …
revolution-like” advancement in terms of progressing the understanding and care of critical …
[HTML][HTML] Timing of antibiotic therapy in the ICU
Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …
[HTML][HTML] Extracorporeal blood purification therapies for sepsis
Extracorporeal blood purification is proposed as an adjuvant therapy for sepsis, aiming at
controlling the associated dysregulation of the immune system, which is known to induce …
controlling the associated dysregulation of the immune system, which is known to induce …
[HTML][HTML] Assessment of a PK/PD target of continuous infusion beta-lactams useful for preventing microbiological failure and/or resistance development in critically ill …
Background: Emerging data suggest that more aggressive beta-lactam PK/PD targets could
minimize the occurrence of microbiological failure and/or resistance development. This …
minimize the occurrence of microbiological failure and/or resistance development. This …
[HTML][HTML] An approach to antibiotic treatment in patients with sepsis
ML Martínez, EP Plata-Menchaca… - Journal of thoracic …, 2020 - ncbi.nlm.nih.gov
Sepsis is a medical emergency and life-threatening condition due to a dysregulated host
response to infection, which is time-dependent and associated with unacceptably high …
response to infection, which is time-dependent and associated with unacceptably high …