Antibiotics are the commonest cause of life-threatening immune-mediated drug reactions
that are considered off-target, including anaphylaxis, and organ-specific and severe …

Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases
that are characterized by widespread epidermal necrosis and sloughing of skin. They are …

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic
symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated …

Drug hypersensitivity may manifest ranging from milder skin reactions (eg, maculopapular
exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions …

Importance Penicillin allergy is a significant public health issue for patients, antimicrobial
stewardship programs, and health services. Validated clinical decision rules are urgently …

Enfortumab vedotin is a first-in-class Nectin-4-directed antibody-drug conjugate approved by
the US Food and Drug Administration for the treatment of patients with locally advanced or …

On 21 January 2021, an interim analysis of a phase-3 clinical trial revealed that the
investigational, recombinant-vector COVID-19 vaccine developed by Janssen …

With the increasing use of targeted anticancer drugs and immunotherapies, there have been
a substantial number of reports concerning life-threatening severe cutaneous adverse …

Delayed drug hypersensitivity reactions are clinically diverse reactions that vary from
isolated benign skin conditions that remit quickly with no or symptomatic treatment, drug …

Objectives Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe,
delayed hypersensitivity reaction (DHR). We observed DRESS to inhibitors of interleukin 1 …