Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and
dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding …

Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol,
which has widespread actions throughout the body. Calcitriol regulates numerous cellular …

Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Combination therapy is frequently used in cancer treatments. Delivery of combined
anticancer agents loaded in a nanocarrier would be a promising option for combination …

A common stage of advanced prostate cancer is castration-resistant prostate cancer
(CRPC), greater understanding of which is required in order to address and solve the …

With the emergence of high-throughput technologies, computational screening based on
gene expression profiles has become one of the most effective methods for drug discovery …

Anoikis is a unique mode of apoptotic cell death that occurs consequentially to insufficient
cell-matrix interactions. Resistance to anoikis is a critical contributor to tumor invasion and …

Prostate cancer is the most frequent malignancy in the worldwide male population; it is also
one of the most common among all the leading cancer-related death causes. In the last two …

Prostate cancer is the second leading cause of cancer deaths in the USA. The challenge in
managing castration-resistant prostate cancer (CRPC) stems not from the lack of therapeutic …

Currently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease,
stroke and osteoporosis are increasing fast and fast. It's critical necessary to discovery lead …