Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current
therapies. In this brief review, we provide an update regarding the use of animal models to …

Among the four G protein–coupled receptors (H1–H4) identified as mediators of the biologic
effects of histamine, the H3 receptor (H3R) is distinguished for its almost exclusive …

Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …

In recent years, evidence supporting a link between inflammation and neuropsychiatric
disorders has been mounting. Autism spectrum disorders (ASD) and schizophrenia share …

Highlights•Genetic and functional studies have provided important evidence pointing toward
a central role for dendritic spines on the pathogenesis of neuropsychiatric conditions.•Many …

Maternal infection during pregnancy and childhood social trauma have been associated
with neurodevelopmental and affective disorders, such as schizophrenia, autism spectrum …

Ethnopharmacological relevance Persistent ketamine insults to the central nervous system
block NMDA receptors and disrupt putative neurotransmission, oxido–nitrosative, and …

Schizophrenia is a severe disorder characterized by positive, negative and cognitive
symptoms, which are still not fully understood. The development of efficient antipsychotics …

Cardiovascular, rheumatic, kidney, and neurodegenerative diseases and mental disorders
are a common cause of deterioration in the quality of life up to severe disability and death …

Healthy brain function requires a balance between the activity of dopamine receptor 1 (D1)
and dopamine receptor 2 (D2). Alterations in this balance increase the risk for numerous …