In severe SARS-CoV-2 infections, emerging data including recent histopathological studies
have emphasized the crucial role of endothelial cells (ECs) in vascular dysfunction …

The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of
homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and …

IL-6 contributes to host defense against infections and tissue injuries. However,
exaggerated, excessive synthesis of IL-6 while fighting environmental stress leads to an …

Neurotoxicity is an important and common complication of chimeric antigen receptor-T cell
therapies. Acute neurologic signs and/or symptoms occur in a significant proportion of …

The endothelium, a tissue that forms a single layer of cells lining various organs and cavities
of the body, especially the heart and blood as well as lymphatic vessels, plays a complex …

The acute phase response Infection The acute phase response is the answer of the
organism Tissue injury to disturbances of its homeostasis due to infection, tissue …

The promoter region of the interleukin-6 (IL-6) gene has a putative NF-κb-binding site. We
found that a fragment of the IL-6 promoter containing the site specifically binds highly …

Abstract Interleukin-6 (IL-6) is a cytokine originally identified almost 30 years ago as a B-cell
differentiation factor, capable of inducing the maturation of B cells into antibody-producing …

Publisher Summary This chapter focuses on structure and expression of interleukin-6 (IL-6),
which is a cytokine with pleiotropic activities that plays a central role in host defense. IL-6 …

Tumor necrosis factor (TNF) came to birth in a strange way. It made its entry into the world of
biology and medicine when Lloyd Old discovered that the capacity to induce, in vivo and in …